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Sex-linked barring ...
Sex-linked barring in chickens is controlled by the CDKN2A/B tumour suppressor locus
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- Hellström, Anders R. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University
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- Sundström, Elisabeth (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish University Agriculture Science
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- Gunnarsson, Ulrika (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University
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Bed'hom, Bertrand (author)
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- Tixier-Boichard, Michele (author)
- AgroParisTech
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- Honaker, Christa F. (author)
- Virginia Polytech Institute and State University
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- Sahlqvist, Anna-Stina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe),Uppsala University
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- Jensen, Per (author)
- Linköpings universitet,Zoologi,Tekniska högskolan
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- Kämpe, Olle (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Autoimmuna sjukdomar (Kämpe)
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- Siegel, Paul B. (author)
- AgroParisTech,Virginia Polytech Institute and State University
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- Kerje, Susanne (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Autoimmuna sjukdomar (Kämpe),Uppsala University
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University
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(creator_code:org_t)
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- Blackwell Publishing Group, 2010
- 2010
- English.
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In: Pigment Cell and Melanoma Research. - : Blackwell Publishing Group. - 1755-1471 .- 1755-148X. ; 23:4, s. 521-530
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Sex-linked barring, a common plumage colour found in chickens, is characterized by black and white barred feathers. Previous studies have indicated that the white bands are caused by an absence of melanocytes in the feather follicle during the growth of this region. Here we show that Sex-linked barring is controlled by the CDKN2A/B locus, which encodes the INK4b and ARF transcripts. We identified two non-coding mutations in CDKN2A that showed near complete association with the phenotype. Also identified were two missense mutations at highly conserved sites, V9D and R10C, and every bird tested with a confirmed Sex-linked barring phenotype carried one of these missense mutations. Further work is required to determine if one of these or a combined effect of two or more CDKN2A mutations is causing Sex-linked barring. This novel finding provides the first evidence that the tumour suppressor locus CDKN2A/B can affect pigmentation phenotypes and sheds new light on the functional significance of this gene.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Husdjursvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Animal and Dairy Sience (hsv//eng)
Keyword
- INK4b
- ARF
- CDKN2
- sex-linked barring
- chicken
- melanogenesis
- melanocytes
- MEDICINE
- MEDICIN
- SOCIAL SCIENCES
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Hellström, Ander ...
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Sundström, Elisa ...
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Gunnarsson, Ulri ...
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Bed'hom, Bertran ...
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Tixier-Boichard, ...
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Honaker, Christa ...
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Sahlqvist, Anna- ...
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Jensen, Per
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Kämpe, Olle
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Siegel, Paul B.
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Kerje, Susanne
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Andersson, Leif
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- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Animal and Dairy ...
- Articles in the publication
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Pigment Cell and ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences
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Linköping University